Pregnancy and asthma  
 
 
 

 

     

Pregnancy and Asthma

 
 
 

Effect of Asthma on mothers.
Other diseases mimicking asthma during pregnancy:

Goals of asthma control during pregnancy.

Things to do to control asthma during pregnancy.

When to seek emergency medical help.
Safety of asthma medication during pregnancy.
Immunotherapy during pregnancy: is it safe.
Influenza vaccination during pregnancy.
Safety of different commonly used chemical agents during pregnancy.
Can my child inherit asthma from me.
Is asthma contraindication for pregnancy.

Is there chances of having acute asthma attack during labor.
Can Caesarean section increase my risk of having acute asthma attack.
Can I breast feed my infant as I am on asthma medication.

Which drugs are harmful during delivery and labor?

Asthma is one of the most common potentially life-threatening condition complicating pregnancy. It is also called gestational asthma. The incidence of asthma is increasing steadily and it is estimated that asthma currently affects 4% to 8% of pregnant women. In rare cases asthma may occur for the first time during pregnancy. In general well controlled asthma is not associated with a higher risk of adverse pregnancy outcomes.

In fact the most common cause of worsening  asthma in pregnancy is due to noncompliance with medicines.

It is seen that about one third of the pregnant women with asthma experience worsening of their asthma symptoms during pregnancy.

One third of the asthmatic women feel better during pregnancy.

Asthma exacerbations are more frequent at the beginning of the third trimester of pregnancy and improves a few weeks before labor.

10 % of the pregnant women suffering from asthma seek emergency care during the pregnancy.

Oxygen is vital for the well being of the mother and the fetus. Every pregnant woman needs a proper treatment to maintain normal lung functions and oxygen level to maintain proper oxygen supply to the fetus.

Asthma patient should receive education about maintenance and rescue medication, how to measure PEFR by peak flow meter, proper use of inhalers, asthma prevention, and adherence of asthma action plan. Patient should also learn when the asthma is worsening and when to contact the doctor.

Spirometry is the preferred method for pulmonary function testing during outpatient visits. However, peak expiratory flow measurement with a peak flow meter is also adequate.


Effect of Asthma on pregnant women:

  •  Pre eclampsia.

  •  Placenta previa.

  •  Gestational hypertension.

  •  Prolonged hospital stay.

     Fetal complications include:

  • Increased risk of perinatal mortality

  • Intra uterine growth retardation.

  • Low birth weight.

  • Neo natal hypoxia.

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Other diseases mimicking asthma during pregnancy:

  • Mechanical obstruction

  • Laryngeal obstruction

  • COPD

  • Pulmonary edema

  • Pulmonary embolism

  • Amniotic fluid embolism

  • Upper airway cough (Rhinitis, sinusitis, reflux)

  • Carcinoid syndrome.

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Goals of asthma control during pregnancy:

The American College of Obstetricians and Gynecologists (ACOG) has issued a practice bulletin for management of asthma during pregnancy. The new recommendations appear in the February issue of Obstetrics & Gynecology 2008. They are:

  • Prevent hypoxic episodes in mother there by maintaining adequate fetal oxygenation.

  • Monitor lung functions by spirometer preferred.

  • Avoid and controlling asthma triggers.

  • Patient education

  • Individualized pharmacotherapy to maintain normal pulmonary functions.

  • Control day time and nocturnal symptoms.

  • Maintain normal activity levels including exercise.

  • Prevent acute exacerbations of asthma.

  • No emergency department visit or hospitalization.

  • Avoid adverse effects of medications to mother and child.

  • Give birth to a healthy child.

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Things to do to control asthma during pregnancy:

  • Identify and control asthma triggers.

  • Eliminate all exposure to tobacco smoke (active or passive).

  • Take proper treatment of asthma.

  • Ask for a written Asthma action plan from your doctor.

  • Identify worsening of asthma and go for prompt treatment.

  • Continue your regularly scheduled asthma medication during labor and delivery.

  • PEFR of the patient should be measured regularly.


When to seek emergency medical help?

Patient should seek medical help in emergency department or hospital if any of the following occur:

  1. If therapy does not provide rapid improvement.

  2. Improvement is not sustained.

  3. If there is worsening of asthma symptoms.

  4. If asthma exacerbation is severe.

  5. If fetal kick count decreases.

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Safety of asthma medication during pregnancy:

Oral medications have been usually found safe during pregnancy but recent study shows that oral steroid and theophylline can cause increased incidence of premature birth. Incidence of premature birth can increase up to three fold when oral steroid is taken or two or more medications are taken during pregnancy.

Theophylline: 
Some studies have shown that theophylline can cause increased incidence of premature birth. When two medications are taken specially theophylline and oral steroid the risk of premature birth increases three fold.

But recent studies have given clean chit to theophylline but it is necessary to measure serum theophylline levels during pregnancy. Since protein binding decreases during pregnancy, this may result in increased free drug levels with normal doses. It is recommended to take theophylline in lower doses.

Beta2- adrenergic agonists: 
No adverse effect has been noted on fetus or infant on motherís milk. For pregnant women with asthma, recommended rescue therapy is inhaled albuterol (Salbutamol).

Corticosteroids: 
Oral corticosteroid has shown to increase the risk of premature birth in some studies. This risk increases three fold when they are given with theophylline. Oral corticosteroids used by mother are not a contraindication to breast feeding.

Inhaled steroids are safe during pregnancy and lactation. For persistent asthma during pregnancy, first-line controller therapy consists of inhaled corticosteroids. During pregnancy, budesonide is the preferred inhaled corticosteroid. Though systemic absorption can occur, low plasma levels achieved by inhalation make it unlikely that fetal effects will be seen.

Anti cholinergic agents:
Ipratropium is used less frequently for asthma, but is devoid of any adverse effect.

Cromolyn sodium:
Animal and human studies suggest little potential for fetal harm.

Nedocromil sodium: 
There is not sufficient data for this new drug, which is similar to Cromolyn sodium.

Leukotriene receptor antagonist:
Leukotriene receptor antagonist like zafirlukast and montelukast are probably safe in pregnancy but use should be limited to special circumstances, where they are viewed essential for asthma control.
Zileuton should not be used in pregnancy.

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Immunotherapy (allergy shots) during pregnancy, is it safe?

A number of reports have appeared describing immunotherapy without apparent adverse effects on human pregnancy. Anaphylaxis during pregnancy is a potential risk for mother and fetus.
Patients already receiving immunotherapy and are near maintenance dose or are benefited by it are advised to continue immunotherapy. However it is generally advised not to begin immunotherapy during pregnancy.


Influenza vaccination during pregnancy:

Influenza vaccine is a killed virus vaccine. No adverse outcome to the fetus has been noted in two studies including 245 women.

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Safety of different commonly used chemical agents during pregnancy:

Tannic acid:
Tannic acid is some times used to denature environmental cat or dust mite antigen. There is no published data on exposure to this agent during pregnancy, so its better to avoid.

Benzyl benzoate:
Benzyl benzoate is an ascaricide used to clear dust mites from an environment. Teratogenicity tests have been negative in rats and mice. No human studies reported, itís better to avoid.

Boric acid:
Boric acid is used as insecticide in eliminating cockroaches. Feeding boric acid to pregnant rats has not shown any adverse effect in the course of pregnancy or on fetus. An evaluation of 253 pregnancies with early exposure to boric acid was unable to identify a significant increase in the incidence of birth defects in the offspring.

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Can my child inherit asthma from me?

Though asthma is in most cases a heredity disease but not all the offspring of a asthmatic mother develop asthma. Smoking during pregnancy increases the likelihood of fetus developing asthma later on.


Is asthma contraindication for pregnancy?

Asthma should in no way considered a contraindication to pregnancy, and when asthma is properly controlled, pregnant women with asthma can maintain a normal pregnancy with little or no increased risk to themselves or their fetus.


Is there chances of having acute asthma attack during labour?

Acute asthma attack is very rare in labour due to endogenous steroid production. Asthma medication should be continued as usual during labour. Caesarean section should be reserved for acute severe asthma patients or patients with usual obstetric indications.


Can Caesarean section increase my risk of having acute asthma attack?

Studies and data suggest there is increased risk of postpartum exacerbation of asthma in women having Caesarean section. Many factors such as postoperative pain with diaphragmatic splinting, hypoventilation and atelectasis may be responsible for deteoration of asthma.

Also Caesarean section is planned in patients with severe asthma so chances of acute attack is higher after words.


Can I breast feed my infant as I am on asthma medication?

Women with asthma are encouraged to breast feed. Breast feeding for between 1 and 6 months reduces the later prevalence of atopy in 17 years olds by about 30-50 %. However breast feeding does not appear to protect the offspring from developing asthma.

The safety of older asthma medications including steroid and theophylline tablets has been documented in many studies. Inhalers including steroids inhalers are also found to be safe during lactation. Newer asthma medications should be used in line with manufacturer's recommendations.


Which drugs are harmful during delivery and labor?

A number of drugs often used at the time of labor and delivery should not be used in patients with asthma. Ergometrine and other ergot derivatives, dinoprost can cause severe bronchospasm, specially when used in combination with general anesthesia.

Morphine and meperidine (pethidine are commonly used analgesic drugs during labor. Both can cause bronchoconstriction through histamine release. However in practice this does not happen in majority of women.


Note: Please consult your doctor if you are having asthma and want to conceive or already pregnant. This article is intended to help you understand asthma and pregnancy  better but cannot replace doctors consultation.


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